1. Introduction
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Introductory Lecture by Alex Zhavoronkov, PhD, founder and CEO of Insilico Medicine (31:24)
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Drug Target Discovery - Definitions (8:15)
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Brief History of Drug Target Discovery (8:33)
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Target-centric Approach In Drug Discovery (8:55)
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Drug Development Funnel (6:01)
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Importance of the Target Selection: Phase 2 Failures (3:41)
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Proteins and Other Types of Biological Molecules as Targets (11:51)
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Who Discovers Targets in the Modern World (7:00)
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Complexity and Diversity of the Target Discovery Tasks (8:32)
2. Target Selection Criteria
3. Target Discovery Landscape Nowadays
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Major achievements and failures of the pharma companies in the last 20 years (6:35)
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Top pharma companies and their pipelines nowadays (6:00)
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The most crowded and abandoned therapeutic areas. Phase transition success and likelihood of approval (8:22)
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Innovation at big pharma vs small biotech (4:44)
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Successful repurposing within and across disease areas (4:52)
4. Computational Approach in Target Discovery
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Why Use AI for Target Selection? (7:09)
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Omics Data Types - Advantages and Downsides (7:30)
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Use of Biological Graphs (11:33)
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Text Data and Prior Knowledge (13:08)
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Examples of the Tools for Drug Target Discovery (11:53)
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Applications of Single Cell Data in Drug Discovery (9:55)
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Omics Data Analysis Put in the Context of Prior Knowledge (5:03)
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Challenges in Multi-Omics Computational Approaches to Target Selection (6:18)
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Validation of Computational Approaches to Target Selection (9:06)
5. Computational Approach in Target Discovery: Case Studies
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Previous Attempts and Growing Role of Computational Methods to Meet Target Selection Criteria (14:16)
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AI for Target Discovery (14:07)
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AI for Target Discovery: Case Studies (25:57)
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PandaOmics Target ID Page (3:52)
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Exercise: Novel Small Molecules Targets for Liver Cirrhosis
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Exercise: Novel Antibody Targets for Sarcoma
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Exercise: Common Targets for Familial and Sporadic Amyotrophic Lateral Sclerosis
6. Target Combinations
7. Extended Target Discovery: Current and Future Trends
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New Therapeutic Modalities (20:27)
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Evolution of the Druggable Genome Concept (10:49)
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Untargeted to Targeted - Re-Evaluation of the Mechanism of Action and Toxicity for Old Drugs (5:02)
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Indication Expansion and Prioritization (8:27)
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Target Discovery and Senolytics (7:38)
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Large Language Models in Drug Discovery (2:41)
